Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 5/20 | 0.58 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.58 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | ESRRA | P11474 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429827 | 0.82 | HPGD (0.61) | IGF1RPIM1PIM2HPGD | |
| SCHEMBL9429040 | 0.82 | PYGL (0.56) | PIM1PIM2HPGDGSK3B | |
| SCHEMBL9311363 | 0.82 | ALDH1A1 (0.46) | HPGDRAB9AMEN1KMT2A | |
| SCHEMBL9312842 | 0.81 | HPGD (0.61) | PIM1PIM2HPGDAKR1B1 | |
| SCHEMBL1299479 | 0.75 | PIM1 (1.00) | IGF1RPIM1PIM2PIM3HPGD | |
| SCHEMBL2546354 | 0.75 | PIM1 (1.00) | IGF1RPIM1PIM2PIM3HPGD | |
| SCHEMBL1299480 | 0.75 | PIM1 (1.00) | IGF1RPIM1PIM2PIM3HPGD | |
| SCHEMBL2424658 | 0.74 | PDE4B (1.00) | IGF1RPIM1PIM2PIM3PDE4B | |
| SCHEMBL31521577 | 0.74 | PDE4B (1.00) | IGF1RPIM1PIM2PIM3PDE4B | |
| SCHEMBL15421515 | 0.74 | PDE4B (1.00) | IGF1RPIM1PIM2PIM3PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330999-A | Diabetes, obesity | ADIR ET COMPAGNIE (FR) | 1994-07-19 | — | — | US | disclosed |
| US-5266582-A | Antidiabetic agents | ADIR ET COMPAGNIE (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0528734-A1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-02-24 | — | — | EP | disclosed |