Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.51 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | RPLP1 | P05386 | 2/20 | 0.38 |
| ▸ | RPLP0 | P05388 | 2/20 | 0.38 |
| ▸ | RPS17 | P08708 | 2/20 | 0.38 |
| ▸ | RPSA | P08865 | 2/20 | 0.38 |
| ▸ | RPS2 | P15880 | 2/20 | 0.38 |
| ▸ | RPL35A | P18077 | 2/20 | 0.38 |
| ▸ | RPL7 | P18124 | 2/20 | 0.38 |
| ▸ | RPL17 | P18621 | 2/20 | 0.38 |
| ▸ | RPS4Y1 | P22090 | 2/20 | 0.38 |
| ▸ | RPS3 | P23396 | 2/20 | 0.38 |
| ▸ | RPS12 | P25398 | 2/20 | 0.38 |
| ▸ | RPL13 | P26373 | 2/20 | 0.38 |
| ▸ | RPL10 | P27635 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429926 | 0.86 | SLC6A4 (0.44) | TRPM8MC4RSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9428924 | 0.86 | SLC6A4 (0.44) | TRPM8SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL9429947 | 0.85 | SLC6A4 (0.46) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL9429217 | 0.83 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL9429644 | 0.82 | APP (0.37) | TRPM8MC4RALDH1A1SMN1; SMN2 | |
| SCHEMBL9428421 | 0.81 | RAB9A (0.39) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL8377826 | 0.81 | SLC6A3 (0.40) | TRPM8SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL8379418 | 0.79 | SLC6A4 (0.44) | TRPM8SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL9428898 | 0.76 | SLC6A4 (0.41) | TRPM8SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL11301763 | 0.74 | CA1 (0.51) | TRPM8MC4RSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| EP-0440503-A1 | 4-Isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-08-07 | — | — | EP | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |