Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | CCKBR | P32239 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429364 | 0.89 | PTGS2 (0.62) | PTGS2HTTTP53SMN1; SMN2TRPV1 | |
| SCHEMBL9428482 | 0.87 | HTT (0.54) | PTGS2HTTNPC1RAB9ATP53 | |
| SCHEMBL9429928 | 0.85 | HTT (0.53) | PTGS2HTTNPC1RAB9ATP53 | |
| SCHEMBL7880670 | 0.84 | LMNA (0.56) | PTGS2HTTNPC1RAB9ATP53 | |
| SCHEMBL9429561 | 0.84 | TP53 (0.47) | PTGS2HTTNPC1RAB9ATP53 | |
| SCHEMBL9428786 | 0.84 | HTT (0.65) | PTGS2HTTNPC1RAB9ATP53 | |
| SCHEMBL9429597 | 0.84 | HTT (0.51) | PTGS2HTTNPC1RAB9ATP53 | |
| SCHEMBL9429816 | 0.82 | NPC1 (0.49) | PTGS2HTTNPC1RAB9ATP53 | |
| SCHEMBL9429927 | 0.81 | HTT (0.56) | PTGS2HTTNPC1RAB9ATP53 | |
| SCHEMBL9429291 | 0.81 | HTT (0.53) | PTGS2HTTNPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |