Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.58 |
| ▸ | HTR2C | P28335 | 6/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | NOS2 | P35228 | 2/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | TLR2 | O60603 | 2/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7067527 | 0.87 | PRCP (0.62) | PRCPHTR2CHTR2BNOS2NOS3 | |
| SCHEMBL5493700 | 0.87 | PRCP (0.62) | PRCPHTR2CHTR2BNOS2NOS3 | |
| SCHEMBL12990763 | 0.87 | PRCP (0.62) | PRCPHTR2CHTR2BNOS2NOS3 | |
| SCHEMBL15329272 | 0.86 | PRCP (0.70) | PRCPHTR2CHTR2BNOS2TLR2 | |
| SCHEMBL616732 | 0.84 | PRCP (0.68) | PRCPHTR2CHTR2BTLR2TERT | |
| SCHEMBL615383 | 0.84 | PRCP (0.68) | PRCPHTR2CHTR2BTLR2TERT | |
| SCHEMBL496387 | 0.84 | PRCP (0.68) | PRCPHTR2CHTR2BTLR2TERT | |
| SCHEMBL8548319 | 0.84 | PRCP (0.68) | PRCPHTR2CHTR2BNOS2TLR2 | |
| SCHEMBL5498791 | 0.84 | PRCP (0.68) | PRCPHTR2CHTR2BNOS2TLR2 | |
| SCHEMBL2197361 | 0.83 | PRCP (0.54) | PRCPHTR2CHTR2BNOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448935-A1 | SUBSTITUTED 2-CARBOXAMIDE CYCLOAMINO UREAS | Novartis AG (CH) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011000905-A1 | SUBSTITUTED 2-CARBOXAMIDE CYCLOAMINO UREAS | NOVARTIS AG (CH) | 2011-01-06 | — | — | WO | disclosed |