Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | STK4 | Q13043 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9430096 | 0.89 | MTOR (0.43) | LRRK2STK4STK3TRPM8MTOR | |
| SCHEMBL9404296 | 0.81 | HTT (0.44) | LRRK2PIK3CBPOLBMAPK1SMN1; SMN2 | |
| SCHEMBL9404413 | 0.79 | KDM4E (0.41) | LRRK2STK4STK3TRPM8MTOR | |
| SCHEMBL9430333 | 0.73 | GABRA1 (0.43) | LRRK2STK4STK3TRPM8PIK3CB | |
| SCHEMBL9404393 | 0.70 | ABL1 (0.40) | LRRK2STK4STK3POLBMAPK1 | |
| SCHEMBL9312142 | 0.70 | POLB (0.40) | LRRK2PIK3CBPIK3CAPOLBCYP1A2 | |
| SCHEMBL9404501 | 0.69 | RXFP1 (0.53) | MTORPIK3CAPOLBUSP2MAPK1 | |
| SCHEMBL7320310 | 0.69 | RXFP1 (0.53) | MTORPIK3CAPOLBCYP1A2CYP3A4 | |
| SCHEMBL9404284 | 0.68 | RXFP1 (0.49) | LRRK2MTORPIK3CBPIK3CAPOLB | |
| SCHEMBL7315229 | 0.64 | RXFP1 (0.69) | MTORPIK3CAPOLBUSP2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |