Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25422032 | 0.83 | PDE3B (0.33) | PDE3BPDE3AMAOAMAOBCDC25B | |
| SCHEMBL71577 | 0.67 | — | — | |
| SCHEMBL10585694 | 0.66 | — | — | |
| SCHEMBL19445110 | 0.62 | TDP1 (0.33) | PDE3BPDE3A | |
| SCHEMBL13407 | 0.61 | — | — | |
| SCHEMBL5333364 | 0.61 | SIGMAR1 (0.42) | PDE3BPDE3AMAOAMAOBCDC25B | |
| SCHEMBL29395256 | 0.61 | SIGMAR1 (0.42) | PDE3BPDE3AMAOAMAOBCDC25B | |
| SCHEMBL21332894 | 0.61 | MAOA (0.43) | PDE3BPDE3AMAOAMAOBCDC25B | |
| Hydrochloric Acid SCHEMBL5740537 | 0.60 | SIGMAR1 (0.41) | PDE3BPDE3AMAOAMAOB | |
| SCHEMBL31095199 | 0.59 | GAA (0.44) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373015-A | Treating hypertension and congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-12-13 | — | — | US | claimed |
| CN-101454319-B | Novel heterocyclic compound or salt thereof and intermediate thereof | TOYAMA CHEMICAL CO LTD | 2012-06-27 | — | — | CN | disclosed |
| CN-101454319-A | Novel heterocyclic compound or salt thereof and intermediate thereof | TOYAMA CHEMICAL CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |