Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.41 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856163 | 0.84 | MMP9 (0.43) | MMP9MMP13ADAM17PPARGPPARA | |
| SCHEMBL8856229 | 0.81 | KDM4E (0.51) | MMP9MMP13ADAM17MAPT | |
| SCHEMBL8856207 | 0.81 | KDM4E (0.51) | MMP9MMP13ADAM17MAPT | |
| SCHEMBL8856210 | 0.76 | MMP9 (0.42) | MMP9MMP13ADAM17PPARGPPARA | |
| SCHEMBL8325823 | 0.74 | ALOX5 (0.47) | MMP9MMP13ADAM17PPARGPPARA | |
| SCHEMBL9840116 | 0.74 | LMNA (0.46) | MMP9MMP13ADAM17PPARGPPARA | |
| SCHEMBL8856098 | 0.73 | KDM4E (0.49) | MMP9MMP13ADAM17MAPT | |
| SCHEMBL8856362 | 0.72 | MMP9 (0.44) | MMP9MMP13ADAM17PPARGPPARA | |
| SCHEMBL8856332 | 0.72 | MMP9 (0.44) | MMP9MMP13ADAM17PPARGPPARA | |
| SCHEMBL6933064 | 0.70 | MMP9 (0.64) | MMP9MMP13ADAM17PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |