Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.40 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1569667 | 0.89 | KDM4C (0.43) | TRPV1PTGDR2KDM4C | |
| SCHEMBL6994371 | 0.86 | GRM7 (0.46) | GRM7SLC6A3SLC6A4HCRTR2KDM4E | |
| SCHEMBL26488602 | 0.83 | MAP3K14 (0.46) | PTGDR2HCRTR2NPC1 | |
| SCHEMBL5846862 | 0.83 | SLC6A4 (0.39) | SLC6A3SLC6A4 | |
| SCHEMBL5846869 | 0.83 | SLC6A4 (0.39) | SLC6A3SLC6A4 | |
| SCHEMBL23705293 | 0.83 | ADRA2A (0.42) | PTGDR2SLC6A3SLC6A4HCRTR2NPC1 | |
| SCHEMBL5846860 | 0.83 | SLC6A4 (0.39) | SLC6A3SLC6A4 | |
| SCHEMBL1846438 | 0.82 | PTGDR2 (0.45) | TRPV1PTGDR2GRM7 | |
| SCHEMBL915090 | 0.81 | MAOB (0.38) | TRPV1PTGDR2KDM4CKDM4EALDH1A1 | |
| SCHEMBL6527466 | 0.80 | PTGDR2 (0.38) | PTGDR2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294635-A | Heterocyclic compounds as aldose reductase inhibitors | PFIZER, INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0530198-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1991015491-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |
| US-5039672-A | Administering enzyme inhibitors to control diabetes | PFIZER INC. (US) | 1991-08-13 | — | — | US | disclosed |