Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 12/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9432167 | 0.85 | AKR1B1 (0.44) | AKR1B1ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL9432976 | 0.74 | AKR1B1 (0.47) | AKR1B1ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL9432317 | 0.71 | ALDH1A1 (0.37) | ALDH1A1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL9432039 | 0.69 | AKR1B1 (0.42) | AKR1B1ALDH1A1MAPTOPRM1OPRK1 | |
| SCHEMBL9432020 | 0.66 | AKR1B1 (0.50) | AKR1B1MAPT | |
| SCHEMBL9432481 | 0.63 | AKR1B1 (0.49) | AKR1B1 | |
| SCHEMBL19839389 | 0.61 | ALDH1A1 (0.50) | ALDH1A1KCNA5 | |
| SCHEMBL10487558 | 0.59 | AKR1B1 (0.50) | AKR1B1 | |
| SCHEMBL10487556 | 0.59 | AKR1B1 (0.50) | AKR1B1 | |
| SCHEMBL14028930 | 0.59 | ALDH1A1 (0.50) | ALDH1A1KCNA5GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294635-A | Heterocyclic compounds as aldose reductase inhibitors | PFIZER, INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0530198-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1991015491-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |
| US-5039672-A | Administering enzyme inhibitors to control diabetes | PFIZER INC. (US) | 1991-08-13 | — | — | US | disclosed |