Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.50 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9598846 | 0.85 | ALOX5 (0.70) | ALOX5 | |
| SCHEMBL9433684 | 0.85 | ALOX5 (0.54) | ALOX5CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL10543748 | 0.78 | CYSLTR1 (0.64) | CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9433713 | 0.76 | AR (0.51) | ALOX5 | |
| SCHEMBL10632386 | 0.73 | CYSLTR1 (0.53) | ALOX5CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10635391 | 0.73 | CYSLTR1 (0.55) | ALOX5CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10632693 | 0.71 | CYSLTR1 (0.53) | ALOX5CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6088376 | 0.71 | CYSLTR1 (0.72) | CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL10636229 | 0.71 | CYSLTR1 (0.57) | ALOX5CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL9369864 | 0.70 | ALOX5 (0.76) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283245-A | Antiinflammatory agent, antiallergens | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-01 | — | — | US | disclosed |
| EP-0381375-B1 | HETEROCYCLIC DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-11-11 | — | — | EP | disclosed |
| US-5089495-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (FR) | 1992-02-18 | — | — | US | disclosed |
| EP-0381375-A1 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-08-08 | — | — | EP | disclosed |