Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 14/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9434229 | 0.81 | AR (0.55) | ARALOX5NR1H2PRKDC | |
| SCHEMBL9598846 | 0.79 | ALOX5 (0.70) | ALOX5 | |
| SCHEMBL9433149 | 0.76 | ALOX5 (0.52) | ALOX5 | |
| SCHEMBL8682014 | 0.73 | AR (0.52) | ARALOX5NR1H2PRKDC | |
| SCHEMBL8617994 | 0.72 | AR (0.53) | ARALOX5NR1H2PRKDCCNR1 | |
| SCHEMBL10681669 | 0.71 | RORA (0.55) | ARNR1H2 | |
| SCHEMBL23838094 | 0.70 | HSD11B1 (0.50) | NR1H2 | |
| SCHEMBL21087697 | 0.70 | HSD11B1 (0.50) | NR1H2 | |
| SCHEMBL16132424 | 0.69 | AHR (0.49) | — | |
| SCHEMBL8617770 | 0.69 | AR (0.50) | ARALOX5NR1H2PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283245-A | Antiinflammatory agent, antiallergens | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-01 | — | — | US | disclosed |
| US-5196422-A | Antiinflammatory agents, antiallergens | ICI PHARMA (FR) | 1993-03-23 | — | — | US | disclosed |
| EP-0381375-B1 | HETEROCYCLIC DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-11-11 | — | — | EP | disclosed |
| US-5089513-A | Antiinflammatory agents; antiallergens; asthma; side effect reduction | ICI PHARMA (FR) | 1992-02-18 | — | — | US | disclosed |
| US-5089495-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (FR) | 1992-02-18 | — | — | US | disclosed |