Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 14/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7813254 | 0.81 | ALOX5 (0.60) | ALOX5 | |
| SCHEMBL9369962 | 0.81 | ALOX5 (0.60) | ALOX5 | |
| SCHEMBL9434229 | 0.79 | AR (0.55) | KCNH2ALOX5PRKDC | |
| SCHEMBL9433089 | 0.77 | ALOX5 (0.45) | KCNH2ALOX5PRKDCCASR | |
| SCHEMBL8682794 | 0.76 | ALDH1A1 (0.40) | KCNH2ALOX5PRKDC | |
| SCHEMBL8614144 | 0.76 | KCNH2 (0.38) | KCNH2ALOX5PRKDCCASR | |
| SCHEMBL29605276 | 0.75 | KCNH2 (0.41) | KCNH2ALOX5PRKDC | |
| SCHEMBL31584832 | 0.74 | CASR (0.46) | KCNH2ALOX5PRKDCCASR | |
| SCHEMBL8612881 | 0.73 | AR (0.36) | KCNH2ALOX5PRKDC | |
| SCHEMBL2984624 | 0.73 | KCNH2 (0.41) | KCNH2ALOX5PRKDCCASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283245-A | Antiinflammatory agent, antiallergens | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-01 | — | — | US | disclosed |
| US-5089495-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (FR) | 1992-02-18 | — | — | US | disclosed |
| EP-0381375-A1 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-08-08 | — | — | EP | disclosed |