Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324448 | 0.81 | P2RX7 (0.38) | ALDH1A1P2RX7KMT2AMEN1SLC9A1 | |
| SCHEMBL4403732 | 0.77 | P2RX7 (0.81) | ALDH1A1P2RX7KMT2ALMNAHDAC6 | |
| SCHEMBL2649520 | 0.74 | SMN1; SMN2 (0.41) | ALDH1A1P2RX7LMNASLC9A1 | |
| SCHEMBL15475138 | 0.73 | P2RX7 (0.52) | ALDH1A1P2RX7LMNAHDAC6SLC9A1 | |
| SCHEMBL6357277 | 0.73 | ALDH1A1 (1.00) | ALDH1A1P2RX7KMT2ALMNA | |
| SCHEMBL6357225 | 0.72 | P2RX7 (0.72) | ALDH1A1P2RX7KMT2ALMNAHDAC6 | |
| SCHEMBL5815309 | 0.72 | P2RX7 (0.71) | ALDH1A1P2RX7KMT2ALMNA | |
| SCHEMBL5815858 | 0.72 | P2RX7 (0.81) | ALDH1A1P2RX7KMT2ALMNA | |
| SCHEMBL5820209 | 0.72 | P2RX7 (0.72) | ALDH1A1P2RX7KMT2ALMNAHDAC6 | |
| SCHEMBL3035928 | 0.72 | LMNA (0.62) | ALDH1A1P2RX7KMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323816-A1 | NOVEL PYRAZOLE DERIVATIVE | Green Tech Co., Ltd. (JP) | 2018-05-23 | — | — | EP | disclosed |
| US-9399635-B2 | Pyrazole derivative | GREEN TECH CO., LTD. (JP) | 2016-07-26 | — | — | US | disclosed |
| US-20140088029-A1 | NOVEL PYRAZOLE DERIVATIVE | PHARMA EIGHT CO., LTD. (JP) | 2014-03-27 | — | — | US | disclosed |
| EP-2698368-A1 | NOVEL PYRAZOLE DERIVATIVE | Pharma Eight Co. Ltd (JP) | 2014-02-19 | — | — | EP | disclosed |
| WO-1994011365-A1 | SUBSTITUTED BENZIMIDAZOLES AND QUINAZOLINES AS ANTIHYPERTENSIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088029-A1 | NOVEL PYRAZOLE DERIVATIVE | PSEN2, MAPT, PSEN1 | ALDH1A1 675/4885P2RX7 2874/4885KMT2A 2085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.