Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.37 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8887438 | 0.85 | HDAC1 (0.40) | HDAC6HDAC1HDAC2CA14KDM4A | |
| SCHEMBL21937996 | 0.83 | CA14 (0.41) | HDAC6HDAC1HDAC2CA14L3MBTL1 | |
| SCHEMBL24172307 | 0.81 | CA12 (0.39) | HDAC6HDAC1HDAC2CA14KDM4C | |
| SCHEMBL4061706 | 0.81 | TDP1 (0.42) | HDAC6HDAC1HDAC2CA14L3MBTL1 | |
| SCHEMBL9434997 | 0.81 | CA14 (0.43) | HDAC6HDAC1HDAC2CA14KDM4A | |
| SCHEMBL7707701 | 0.79 | KDM4A (0.47) | KDM4AHIF1ATET2DOHHKDM4E | |
| SCHEMBL1156357 | 0.79 | KDM4A (0.47) | KDM4AHIF1ATET2DOHHKDM4E | |
| SCHEMBL8746938 | 0.79 | KDM4A (0.47) | KDM4AHIF1ATET2DOHHKDM4E | |
| SCHEMBL19784441 | 0.77 | HDAC1 (0.44) | HDAC6HDAC1HDAC2GAASMN1; SMN2 | |
| SCHEMBL1222571 | 0.76 | HDAC6 (0.36) | HDAC6HDAC1HDAC2CA14L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994011367-A1 | 2-(PYRID-2'-YL)-2-THIAZOLINE-4(S)-CARBOXYLIC ACID DERIVATIVES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC. (US) | 1994-05-26 | — | — | WO | disclosed |