Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9435672 | 1.00 | MAPT (0.59) | MAPTHTR7SMN1; SMN2ABCB1NPSR1 | |
| SCHEMBL9435493 | 0.90 | L3MBTL1 (0.56) | — | |
| SCHEMBL9435486 | 0.90 | L3MBTL1 (0.56) | — | |
| SCHEMBL9098366 | 0.88 | TSHR (0.52) | MAPTABCB1 | |
| SCHEMBL9098349 | 0.88 | TSHR (0.52) | MAPTABCB1 | |
| SCHEMBL9098357 | 0.88 | TSHR (0.52) | MAPTABCB1 | |
| SCHEMBL9435307 | 0.86 | DRD4 (0.58) | MAPT | |
| SCHEMBL9435302 | 0.86 | DRD4 (0.58) | MAPT | |
| SCHEMBL9435831 | 0.85 | GAA (0.50) | ABCB1 | |
| SCHEMBL9435300 | 0.83 | MAPT (0.52) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371088-A | 1-aryl-4-piperazinylcyclohexanecarbonitriles, the preparation and use thereof | BASF AKTIENGESELLSCHAFT (DE) | 1994-12-06 | — | — | US | disclosed |