Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aminosalicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.81 |
| ▸ | MAPT | P10636 | 5/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.81 |
| ▸ | GAA | P10253 | 2/20 | 0.81 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.81 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.81 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminosalicylic Acid SCHEMBL3333393 | 0.90 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTCYP3A4GAA | |
| Aminosalicylic Acid SCHEMBL29450213 | 0.90 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTCYP3A4GAA | |
| Aminosalicylic Acid SCHEMBL2262 | 0.90 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTCYP3A4GAA | |
| Aminosalicylic Acid SCHEMBL30337954 | 0.90 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTCYP3A4GAA | |
| Aminosalicylic Acid SCHEMBL27779882 | 0.89 | ALDH1A1 (0.76) | ALDH1A1KDM4EMAPTCYP3A4GAA | |
| Aminosalicylic Acid SCHEMBL28886739 | 0.88 | ALDH1A1 (0.96) | ALDH1A1KDM4EMAPTCYP3A4GAA | |
| Aminosalicylic Acid SCHEMBL11788850 | 0.88 | ALDH1A1 (0.96) | ALDH1A1KDM4EMAPTCYP3A4GAA | |
| Aminosalicylic Acid SCHEMBL1047422 | 0.88 | ALDH1A1 (0.96) | ALDH1A1KDM4EMAPTCYP3A4GAA | |
| Aminosalicylic Acid SCHEMBL2347251 | 0.88 | ALDH1A1 (0.96) | ALDH1A1KDM4EMAPTCYP3A4GAA | |
| Aminosalicylic Acid SCHEMBL564092 | 0.88 | ALDH1A1 (0.96) | ALDH1A1KDM4EMAPTCYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5322837-A | Stimulating production of red blood cells | GENETICS INSTITUTE, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0209539-B1 | HOMOGENEOUS ERYTHROPOIETIN | GENETICS INSTITUTE, INC. (US) | 1992-05-20 | — | — | EP | disclosed |
| US-5010183-A | Process for purifying DNA and RNA using cationic detergents | QIAGEN N.V. (NL) | 1991-04-23 | — | — | US | disclosed |
| EP-0209539-A4 | HOMOGENEOUS ERYTHROPOIETIN. | GENETICS INST (US) | 1988-07-29 | — | — | EP | disclosed |
| US-4677195-A | Method for the purification of erythropoietin and erythropoietin compositions | GENETICS INSTITUTE, INC. (US) | 1987-06-30 | — | — | US | disclosed |
| EP-0209539-A1 | HOMOGENEOUS ERYTHROPOIETIN. | GENETICS INST (US) | 1987-01-28 | — | — | EP | disclosed |
| WO-1986004068-A1 | HOMOGENEOUS ERYTHROPOIETIN | GENETICS INSTITUTE, INC. (US) | 1986-07-17 | — | — | WO | disclosed |