Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.54 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9437726 | 0.85 | HTR1A (0.51) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437818 | 0.83 | HTR1A (0.49) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437707 | 0.78 | HTR1A (0.57) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL8786888 | 0.78 | HTR1A (0.57) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437737 | 0.76 | HTR1A (0.55) | HTR1AHTR2CSIGMAR1HTR1DHTR1B | |
| SCHEMBL9437871 | 0.75 | HTR1A (0.49) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437745 | 0.75 | HTR1A (0.49) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL9437720 | 0.75 | HTR1A (0.51) | HTR1AHTR2CMAOBGABRA1GABRA5 | |
| SCHEMBL9437864 | 0.75 | HTR1A (0.43) | HTR1AHTR2CHTR1DHTR1BSLC6A4 | |
| SCHEMBL8177698 | 0.74 | HTR1A (0.48) | HTR1AHTR2CHTR1DHTR1BSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296477-A | Antidepressants | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5268381-A | Antidepressant or anxiolytic compound | ADIR ET COMPAGNIE (FR) | 1993-12-07 | — | — | US | disclosed |
| US-5225409-A | Serotoninergic disorders; anxiolytic agents; schizophrenia | ADIR ET COMPAGNIE (FR) | 1993-07-06 | — | — | US | disclosed |
| US-5196434-A | Antidepressants, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1993-03-23 | — | — | US | disclosed |