Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | HTR1B | P28222 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | NMT1 | P30419 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9437710 | 0.96 | HTR1A (0.42) | HTR1AHTR2CHTR1BDRD2DRD1 | |
| SCHEMBL9437862 | 0.86 | HTR1A (0.43) | HTR1AHTR2CHTR1BDRD2DRD1 | |
| SCHEMBL9437888 | 0.85 | HTR1A (0.49) | HTR1AHTR2CHTR1BDRD2DRD1 | |
| SCHEMBL9437801 | 0.83 | HTR1A (0.40) | HTR1AHTR2CHTR1BDRD2DRD1 | |
| SCHEMBL9437950 | 0.81 | HTR1A (0.45) | HTR1AHTR2CHTR1BDRD2DRD1 | |
| SCHEMBL9437773 | 0.80 | HTR1A (0.48) | HTR1AHTR2CHTR1BNMT1HTR1D | |
| SCHEMBL9437719 | 0.80 | HTR1A (0.52) | HTR1AHTR2CHTR1BDRD2HTR2A | |
| SCHEMBL9437784 | 0.79 | HTR1A (0.54) | HTR1AHTR2CGABRA1GABRA5 | |
| SCHEMBL9437815 | 0.79 | PARP1 (0.45) | HTR1AHTR1BDRD2DRD1HTR2A | |
| SCHEMBL9437802 | 0.78 | HTR1A (0.49) | HTR1AHTR2CHTR1BDRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296477-A | Antidepressants | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5268381-A | Antidepressant or anxiolytic compound | ADIR ET COMPAGNIE (FR) | 1993-12-07 | — | — | US | disclosed |