Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9437862 | 0.97 | HTR1A (0.43) | HTR1AHTR2CHTR1BDRD2DRD1 | |
| SCHEMBL9437886 | 0.84 | PARP1 (0.44) | HTR1AHTR2CHTR1BDRD2DRD1 | |
| SCHEMBL9437808 | 0.83 | HTR1A (0.45) | HTR1AHTR2CHTR1BDRD2DRD1 | |
| SCHEMBL9437710 | 0.83 | HTR1A (0.42) | HTR1AHTR2CHTR1BDRD2DRD1 | |
| SCHEMBL9593875 | 0.82 | HTR1A (0.50) | HTR1AHTR2CHTR1BDRD2DRD1 | |
| SCHEMBL9437875 | 0.81 | HTR1A (0.47) | HTR1AHTR2CGABRA1GABRA5 | |
| SCHEMBL9437713 | 0.78 | HTR1A (0.45) | HTR1AHTR2CHTR1BHTR1DSLC6A4 | |
| SCHEMBL9437840 | 0.77 | SIGMAR1 (0.43) | — | |
| SCHEMBL9437720 | 0.77 | HTR1A (0.51) | HTR1AHTR2CGABRA1GABRA5 | |
| SCHEMBL9437846 | 0.77 | HTR1A (0.46) | HTR1AHTR2CHTR1BDRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296477-A | Antidepressants | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5268381-A | Antidepressant or anxiolytic compound | ADIR ET COMPAGNIE (FR) | 1993-12-07 | — | — | US | disclosed |