Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 8/20 | 0.41 |
| ▸ | HTR1B | P28222 | 6/20 | 0.41 |
| ▸ | HTR1D | P28221 | 5/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9437874 | 0.84 | PARP1 (0.49) | PARP1NR3C2HTR1AHTR1BHTR1D | |
| SCHEMBL9437710 | 0.82 | HTR1A (0.42) | HTR1AHTR1BHTR1DSLC6A4DRD2 | |
| SCHEMBL9437886 | 0.82 | PARP1 (0.44) | PARP1NR3C2HTR1AHTR1BHTR1D | |
| SCHEMBL9437900 | 0.80 | PARP1 (0.46) | PARP1NR3C2HTR1AHTR1BHTR1D | |
| SCHEMBL9437866 | 0.79 | PARP1 (0.53) | PARP1NR3C2HTR1AHTR1BHTR1D | |
| SCHEMBL9437769 | 0.79 | PARP1 (0.47) | PARP1NR3C2HTR1AHTR1BHTR1D | |
| SCHEMBL9437808 | 0.79 | HTR1A (0.45) | HTR1AHTR1BHTR1DSLC6A4DRD2 | |
| SCHEMBL9437890 | 0.78 | HTR1A (0.47) | PARP1NR3C2HTR1AHTR1BHTR1D | |
| SCHEMBL9437847 | 0.76 | PARP1 (0.54) | PARP1NR3C2HTR1AHTR1BHTR1D | |
| SCHEMBL9437929 | 0.74 | HTR1A (0.43) | HTR1ASLC6A4CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296477-A | Antidepressants | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5268381-A | Antidepressant or anxiolytic compound | ADIR ET COMPAGNIE (FR) | 1993-12-07 | — | — | US | disclosed |