Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.63 |
| ▸ | TTR | P02766 | 1/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12707447 | 0.88 | HDAC6 (0.57) | HDAC6TTRALBMAOACNR1 | |
| SCHEMBL12704769 | 0.85 | TTR (0.60) | HDAC6TTRALBMAOACNR1 | |
| SCHEMBL12909721 | 0.81 | ALDH1A1 (0.65) | HDAC6ELANETDP1NPC1ALDH1A1 | |
| SCHEMBL1675530 | 0.81 | MAOA (0.56) | HDAC6TTRALBMAOACNR1 | |
| SCHEMBL14326103 | 0.80 | HDAC6 (0.77) | HDAC6ELANENPC1ALDH1A1RAB9A | |
| SCHEMBL1675655 | 0.79 | TTR (0.47) | HDAC6TTRALBMAOACNR1 | |
| SCHEMBL20898025 | 0.79 | HSD17B10 (0.62) | HDAC6TTRALBMAOACNR1 | |
| SCHEMBL12945165 | 0.79 | HDAC6 (0.52) | HDAC6ELANETDP1NPC1ALDH1A1 | |
| SCHEMBL1675404 | 0.78 | TTR (0.60) | HDAC6TTRALBMAOACNR1 | |
| SCHEMBL19029396 | 0.77 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338459-B2 | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | FOLDRX PHARMACEUTICALS, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338459-B2 | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | FOLDRX PHARMACEUTICALS, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338459-B2 | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | FOLDRX PHARMACEUTICALS, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| EP-2314584-A1 | 2-(heteroaryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | Foldrx Pharmaceuticals, Inc. (US) | 2011-04-27 | — | — | EP | disclosed |
| EP-2314584-A1 | 2-(heteroaryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | Foldrx Pharmaceuticals, Inc. (US) | 2011-04-27 | — | — | EP | disclosed |
| US-20110092545-A1 | Compounds, Compositions and Methods for Stabilizing Transthyretin and Inhibiting Transthyretin Misfolding | FoldRx Pharmaceuticals, Inc., a Massachusetts corporation | 2011-04-21 | — | — | US | disclosed |
| US-20110092545-A1 | Compounds, Compositions and Methods for Stabilizing Transthyretin and Inhibiting Transthyretin Misfolding | FoldRx Pharmaceuticals, Inc., a Massachusetts corporation | 2011-04-21 | — | — | US | disclosed |
| US-20110092545-A1 | Compounds, Compositions and Methods for Stabilizing Transthyretin and Inhibiting Transthyretin Misfolding | FoldRx Pharmaceuticals, Inc., a Massachusetts corporation | 2011-04-21 | — | — | US | disclosed |
| US-7868033-B2 | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | FOLDRX PHARMACEUTICALS, INC. (US) | 2011-01-11 | — | — | US | disclosed |
| US-7868033-B2 | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | FOLDRX PHARMACEUTICALS, INC. (US) | 2011-01-11 | — | — | US | disclosed |
| US-7868033-B2 | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | FOLDRX PHARMACEUTICALS, INC. (US) | 2011-01-11 | — | — | US | disclosed |
| CN-101198598-A | 2- ((hetero) aryl) -benzoxazole compounds and derivatives thereof, compositions, and methods for stabilizing and inhibiting transthyretin misfolding | FOLDRX PHARMACEUTICALS INC (US) | 2008-06-11 | — | — | CN | disclosed |
| EP-1768968-A1 | 2-((HETERO) ARYL)-BENZOXAZOLE COMPOUNDS AND DERIVATIVES, COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | Foldrx Pharmaceuticals, Inc. (US) | 2007-04-04 | — | — | EP | disclosed |
| US-20050282780-A1 | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | FOLDRX PHARMACEUTICALS, LLC | 2005-12-22 | — | — | US | disclosed |
| WO-2005113523-A1 | 2-((HETERO) ARYL)-BENZOXAZOLE COMPOUNDS AND DERIVATIVES, COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | FOLDRX PHARMACEUTICALS, INC. (US) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092545-A1 | Compounds, Compositions and Methods for Stabilizing Transthyretin and Inhibiting Transthyretin Misfolding | TTR, ALB, TTPA | HDAC6 3180/4885TTR 1/4885ALB 2/4885 |
| US-20050282780-A1 | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | TTR, ALB, TTPA | HDAC6 3180/4885TTR 1/4885ALB 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.