Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | CDC25B | P30305 | 2/20 | 0.47 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
| ▸ | CDC25C | P30307 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6707308 | 0.87 | TNF (0.46) | TSHRALDH1A1HPGDCDC25BBTN3A1 | |
| SCHEMBL7277411 | 0.83 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4ETDP1MAPK1 | |
| SCHEMBL7278827 | 0.83 | ALDH1A1 (0.51) | TSHRALDH1A1HPGDBTN3A1KDM4E | |
| SCHEMBL11490448 | 0.79 | TSHR (0.67) | TSHRALDH1A1HPGDKDM4ETDP1 | |
| SCHEMBL31520212 | 0.79 | TSHR (0.67) | TSHRALDH1A1HPGDKDM4ETDP1 | |
| SCHEMBL15941488 | 0.78 | TSHR (0.48) | TSHRALDH1A1HPGDCDC25BKDM4E | |
| SCHEMBL27493266 | 0.78 | ALDH1A1 (0.53) | TSHRALDH1A1HPGDCDC25BBTN3A1 | |
| SCHEMBL3861740 | 0.77 | HTR1B (0.47) | TSHRALDH1A1HPGDKDM4ETDP1 | |
| SCHEMBL9439384 | 0.77 | KDM4E (0.56) | TSHRALDH1A1HPGDKDM4ETDP1 | |
| SCHEMBL845701 | 0.75 | KMT2A (0.62) | ALDH1A1HPGDCDC25BKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278148-A | Hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1994-01-11 | — | — | US | disclosed |
| US-5250517-A | Hypotensive and cardiotonic agents; cardiac insufficiency | HOFFMANN-LA ROCHE INC. (US) | 1993-10-05 | — | — | US | disclosed |
| US-5140011-A | Hypotensive agents | HOFFMANN-LA ROCHE, INC. (US) | 1992-08-18 | — | — | US | disclosed |
| US-4931591-A | Novel 5-amino-4-hydroxyvaleryl derivatives | CIBA-GEIGY CORPORATION (US) | 1990-06-05 | — | — | US | disclosed |
| US-4727060-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1988-02-23 | — | — | US | disclosed |