Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L11 | O43521 | 2/20 | 0.34 |
| ▸ | BCL2 | P10415 | 2/20 | 0.34 |
| ▸ | BID | P55957 | 2/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9439775 | 0.81 | KDM4E (0.33) | SMN1; SMN2KDM4EKMT2ACA12CA1 | |
| SCHEMBL8997137 | 0.81 | BRD4 (0.36) | LMNASMN1; SMN2P2RX7 | |
| SCHEMBL8997174 | 0.79 | PDE4A (0.38) | ALDH1A1SMN1; SMN2KDM4EKMT2ACNR2 | |
| SCHEMBL9844748 | 0.74 | DRD2 (0.39) | ALDH1A1KDM4EKMT2ATHRBP2RX7 | |
| SCHEMBL9844781 | 0.66 | DRD2 (0.40) | ALDH1A1KDM4EKMT2ATHRBCFTR | |
| SCHEMBL9844745 | 0.64 | MAPT (0.35) | ALDH1A1LMNASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL9439746 | 0.59 | PTGER4 (0.34) | HPGD | |
| SCHEMBL10068017 | 0.57 | CYP1A2 (0.50) | ALDH1A1SMN1; SMN2KDM4EKMT2ACA12 | |
| SCHEMBL699995 | 0.54 | APP (0.50) | ALDH1A1LMNAAPPSNCASMN1; SMN2 | |
| SCHEMBL6030810 | 0.54 | HDAC3 (0.76) | ALDH1A1LMNAKDM4EPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354754-A | Antitumor and -carcinogenic agents; treating human epidermoid carcinoma KB | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-10-11 | — | — | US | disclosed |