Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 3/20 | 0.34 |
| ▸ | RXRB | P28702 | 3/20 | 0.34 |
| ▸ | RXRG | P48443 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13732790 | 0.80 | S1PR1 (0.54) | LTA4HS1PR1S1PR3POLBKDM4E | |
| SCHEMBL9441026 | 0.78 | TSHR (0.58) | S1PR1S1PR3KMORXRARXRB | |
| SCHEMBL9440535 | 0.77 | LTA4H (0.43) | LTA4HS1PR1S1PR3ALDH1A1SIRT2 | |
| SCHEMBL9440941 | 0.77 | SIRT2 (0.56) | LTA4HS1PR1S1PR3ALDH1A1SIRT2 | |
| SCHEMBL10435551 | 0.77 | TSHR (0.44) | LTA4HS1PR1S1PR3KMORXRA | |
| SCHEMBL2056285 | 0.76 | S1PR1 (0.51) | LTA4HS1PR1S1PR3ALDH1A1MAPT | |
| SCHEMBL203844 | 0.76 | LTA4H (0.47) | LTA4HS1PR1S1PR3KMOMAPT | |
| SCHEMBL9833295 | 0.76 | NOTUM (0.51) | LTA4HS1PR1S1PR3KMOKDM4E | |
| SCHEMBL13361932 | 0.74 | DAGLA (0.47) | S1PR1S1PR3RXRARXRBFOLH1 | |
| SCHEMBL4329816 | 0.73 | DAGLA (0.47) | RXRARXRBRXRGTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371098-A | Use of oxazole compounds to treat osteoporosis | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-12-06 | — | — | US | disclosed |
| US-5239080-A | Oxazole compounds and their use as antidiabetic and bone-reduction inhibitory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0440183-A1 | Oxazole compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-07 | — | — | EP | disclosed |
| EP-0382199-A1 | Oxazole compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1990-08-16 | — | — | EP | disclosed |