Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9440535 | 0.84 | LTA4H (0.43) | SIRT2S1PR1S1PR3LTA4HNOTUM | |
| SCHEMBL9440855 | 0.84 | DAGLA (0.46) | SIRT2S1PR1S1PR3ALDH1A1 | |
| SCHEMBL9833295 | 0.83 | NOTUM (0.51) | SIRT2S1PR1S1PR3LTA4HNOTUM | |
| SCHEMBL13732790 | 0.81 | S1PR1 (0.54) | S1PR1S1PR3LTA4HALDH1A1TLR8 | |
| SCHEMBL4178491 | 0.81 | S1PR1 (0.47) | SIRT2S1PR1S1PR3TLR8 | |
| SCHEMBL4329816 | 0.80 | DAGLA (0.47) | ALDH1A1 | |
| SCHEMBL9441026 | 0.79 | TSHR (0.58) | S1PR1S1PR3ALDH1A1 | |
| SCHEMBL9441048 | 0.78 | SIRT2 (0.63) | SIRT2S1PR1S1PR3LTA4HNOTUM | |
| SCHEMBL10435551 | 0.78 | TSHR (0.44) | S1PR1S1PR3LTA4HNPSR1RAB9A | |
| SCHEMBL4322293 | 0.77 | HDAC1 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0382199-A1 | Oxazole compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1990-08-16 | — | — | EP | claimed |
| US-5371098-A | Use of oxazole compounds to treat osteoporosis | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-12-06 | — | — | US | disclosed |
| US-5239080-A | Oxazole compounds and their use as antidiabetic and bone-reduction inhibitory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0440183-A1 | Oxazole compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-07 | — | — | EP | disclosed |
| EP-0382199-A1 | Oxazole compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1990-08-16 | — | — | EP | disclosed |