Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | EBP | Q15125 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9678100 | 0.86 | KCNH2 (0.48) | ABCB1HTR1ASLC6A4LMNAALDH1A1 | |
| SCHEMBL9447564 | 0.85 | ABCB1 (0.45) | ABCB1HTR1ASLC6A4ALDH1A1EBP | |
| SCHEMBL9444495 | 0.84 | KCNH2 (0.58) | ABCB1SMN1; SMN2ALDH1A1MAPTHTT | |
| SCHEMBL9681410 | 0.83 | ABCB1 (0.43) | ABCB1HTR1ASLC6A4ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL9444430 | 0.83 | KCNH2 (0.59) | ABCB1SMN1; SMN2ALDH1A1MAPTHTT | |
| SCHEMBL9041547 | 0.80 | ABCB1 (0.43) | ABCB1HTR1ASLC6A4ALDH1A1HTT | |
| SCHEMBL10645360 | 0.80 | KMT2A (0.54) | ABCB1ALDH1A1MAPTRAB9AEBP | |
| SCHEMBL9028157 | 0.79 | OPRM1 (0.48) | HTT | |
| SCHEMBL9444543 | 0.77 | KDM2B (0.60) | LMNAALDH1A1MAPTHTT | |
| SCHEMBL9444379 | 0.77 | CCR3 (0.49) | HTR1ASLC6A4ALDH1A1HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0235752-B1 | Piperidine derivative, pharmaceutical composition containing the same and use | EISAI CO LTD (JP) | 1993-11-18 | — | — | EP | disclosed |
| US-5179095-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1993-01-12 | — | — | US | disclosed |
| US-5118689-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4996215-A | Antiarrythmia agents | EISAI CO., LTD. (JP) | 1991-02-26 | — | — | US | disclosed |
| EP-0235752-A2 | Piperidine derivative, pharmaceutical composition containing the same and use | Eisai Co., Ltd. (JP) | 1987-09-09 | — | — | EP | disclosed |