Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | QDPR | P09417 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.38 |
| ▸ | CPS1 | P31327 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9444479 | 0.85 | HSD11B1 (0.43) | SMN1; SMN2KCNH2CYP3A4CYP2D6QDPR | |
| Hydrochloric Acid SCHEMBL9444347 | 0.81 | MEN1 (0.43) | SMN1; SMN2CYP2D6POLBKDM4ETDP1 | |
| SCHEMBL9444360 | 0.81 | KCNH2 (0.57) | KCNH2CYP3A4CYP2D6CYP2C19POLB | |
| SCHEMBL9444387 | 0.79 | JAK2 (0.43) | SMN1; SMN2KCNH2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9444338 | 0.79 | HTR2A (0.54) | KCNH2CYP3A4CYP2D6CYP2C19POLB | |
| SCHEMBL10966560 | 0.77 | HSD11B1 (0.50) | QDPRCPS1 | |
| SCHEMBL10634871 | 0.75 | CPS1 (0.60) | SMN1; SMN2CYP3A4CYP2C19QDPRPOLB | |
| SCHEMBL7845841 | 0.74 | ALDH1A1 (0.54) | SMN1; SMN2CYP3A4POLBKDM4ETDP1 | |
| SCHEMBL28939429 | 0.72 | ALDH1A1 (0.62) | SMN1; SMN2POLBKDM4ETDP1ALDH1A1 | |
| SCHEMBL23215765 | 0.71 | HSP90AA1 (0.55) | QDPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0235752-B1 | Piperidine derivative, pharmaceutical composition containing the same and use | EISAI CO LTD (JP) | 1993-11-18 | — | — | EP | disclosed |
| US-5179095-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1993-01-12 | — | — | US | disclosed |
| US-5118689-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4996215-A | Antiarrythmia agents | EISAI CO., LTD. (JP) | 1991-02-26 | — | — | US | disclosed |
| US-4876262-A | ANTIARRHYTHMIA AGENTS | EISAI CO., LTD. (JP) | 1989-10-24 | — | — | US | disclosed |
| EP-0235752-A2 | Piperidine derivative, pharmaceutical composition containing the same and use | Eisai Co., Ltd. (JP) | 1987-09-09 | — | — | EP | disclosed |