Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CPS1 | P31327 | 1/20 | 0.42 |
| ▸ | QDPR | P09417 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9444485 | 0.85 | SMN1; SMN2 (0.43) | CPS1QDPRSMN1; SMN2ALDH1A1REV1 | |
| Hydrochloric Acid SCHEMBL9444506 | 0.83 | KDM1A (0.47) | SMN1; SMN2CYP17A1ALDH1A1KDM2BGLA | |
| SCHEMBL9444322 | 0.80 | ACHE (0.47) | CYP17A1ACHEALDH1A1KDM4EKMT2A | |
| SCHEMBL6712581 | 0.80 | HSD11B1 (0.63) | HSD11B1CPS1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL9444360 | 0.78 | KCNH2 (0.57) | HSD11B1L3MBTL1TP53CYP1A2CYP3A4 | |
| SCHEMBL6281251 | 0.74 | TSHR (0.45) | HSD11B1CPS1SMN1; SMN2L3MBTL1ACHE | |
| SCHEMBL5359155 | 0.74 | ALDH1A1 (0.53) | SMN1; SMN2CYP17A1ALDH1A1GLASLC22A1 | |
| SCHEMBL23215646 | 0.73 | MGLL (0.49) | HSD11B1CPS1QDPRSMN1; SMN2ALDH1A1 | |
| SCHEMBL29745184 | 0.73 | MGLL (0.49) | HSD11B1CPS1QDPRSMN1; SMN2ALDH1A1 | |
| SCHEMBL12970664 | 0.73 | MEN1 (0.52) | SMN1; SMN2CYP17A1ALDH1A1GLASLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0235752-B1 | Piperidine derivative, pharmaceutical composition containing the same and use | EISAI CO LTD (JP) | 1993-11-18 | — | — | EP | disclosed |
| US-5179095-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1993-01-12 | — | — | US | disclosed |
| US-5118689-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4996215-A | Antiarrythmia agents | EISAI CO., LTD. (JP) | 1991-02-26 | — | — | US | disclosed |
| US-4876262-A | ANTIARRHYTHMIA AGENTS | EISAI CO., LTD. (JP) | 1989-10-24 | — | — | US | disclosed |
| EP-0235752-A2 | Piperidine derivative, pharmaceutical composition containing the same and use | Eisai Co., Ltd. (JP) | 1987-09-09 | — | — | EP | disclosed |