Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28047476 | 0.83 | BRD4 (0.40) | BRD4ACHEALOX12MAPTHPGD | |
| SCHEMBL11134630 | 0.80 | GRM2 (0.44) | BRD4ACHEALOX12MAPTHPGD | |
| Allylbenzene SCHEMBL27610997 | 0.73 | MAPK1 (0.33) | BRD4LMNASIGMAR1ALDH1A1 | |
| SCHEMBL11134484 | 0.73 | CYP19A1 (0.45) | LMNAALDH1A1 | |
| SCHEMBL28252209 | 0.69 | L3MBTL1 (0.38) | POLBSIGMAR1ALDH1A1GAA | |
| SCHEMBL28946773 | 0.69 | POLB (0.50) | BRD4ACHELMNAPOLBSIGMAR1 | |
| SCHEMBL8865284 | 0.68 | KCNH2 (0.56) | HPGDTSHRLMNASIGMAR1 | |
| SCHEMBL1974393 | 0.68 | HTR1D (0.52) | BRD4LMNAPOLBSIGMAR1GAA | |
| SCHEMBL27707083 | 0.68 | ALDH1A1 (0.46) | BRD4TSHRLMNAPOLBSIGMAR1 | |
| SCHEMBL11139943 | 0.68 | CYP1A2 (0.43) | ACHESIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250286-A | Treatment of chronic obstructive pulmonary disease (COPD) by inhalation of an imidazoline | AEGIS TECHNOLOGY, INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0527925-A4 | TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) BY INHALATION OF AN IMIDAZOLINE | — | 1993-09-15 | — | — | EP | disclosed |
| EP-0527925-A1 | TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) BY INHALATION OF AN IMIDAZOLINE | AEGIS TECHNOLOGIE, INC. (US) | 1993-02-24 | — | — | EP | disclosed |
| US-5096916-A | Administering tolazoline | AEGIS TECHNOLOGY, INC. (US) | 1992-03-17 | — | — | US | disclosed |
| WO-1991016891-A1 | TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) BY INHALATION OF AN IMIDAZOLINE | AEGIS TECHNOLOGY, INC. (US) | 1991-11-14 | — | — | WO | disclosed |
| US-4411699-A | AMIDINE DERIVATIVES | FUJI PHOTO FILM CO., LTD. (JP) | 1983-10-25 | — | — | US | disclosed |