Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.63 |
| ▸ | ALOX5AP | P20292 | 9/20 | 0.61 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.57 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.57 |
| ▸ | PTGIR | P43119 | 1/20 | 0.56 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9146626 | 0.99 | CYP3A4 (0.63) | CYP3A4CYP2C9LMNACYP1A2TSHR | |
| Water SCHEMBL9146635 | 0.99 | CYP3A4 (0.63) | CYP3A4CYP2C9LMNACYP1A2TSHR | |
| SCHEMBL9680113 | 0.95 | ALOX5AP (0.62) | CYP3A4CYP2C9LMNACYP1A2TSHR | |
| Water SCHEMBL9140717 | 0.94 | ALOX5AP (0.61) | CYP3A4CYP2C9LMNACYP1A2TSHR | |
| Water SCHEMBL9140709 | 0.94 | ALOX5AP (0.61) | CYP3A4CYP2C9LMNACYP1A2TSHR | |
| SCHEMBL9140666 | 0.94 | PLA2G2A (0.65) | CYP3A4CYP2C9LMNACYP1A2TSHR | |
| SCHEMBL2746925 | 0.92 | ALOX5AP (0.68) | CYP3A4CYP2C9LMNACYP1A2TSHR | |
| Hydrochloric Acid SCHEMBL9138311 | 0.92 | ALOX5AP (0.67) | CYP3A4CYP2C9LMNACYP1A2TSHR | |
| SCHEMBL9138282 | 0.92 | PLA2G2A (0.59) | CYP3A4CYP2C9LMNACYP1A2TSHR | |
| SCHEMBL9447721 | 0.92 | PTGS2 (0.64) | PTGDR2ALOX5APPLA2G2APLA2G1BPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229516-A | Antiinflammatory agents, antiallergens and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-07-20 | — | — | US | claimed |
| EP-0502106-A1 | SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-09 | — | — | EP | claimed |
| WO-1991006537-A2 | SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-16 | — | — | WO | claimed |