Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5052635 | 0.83 | PPIA (0.42) | MEN1LMNAKMT2ATGM2 | |
| Hydrochloric Acid SCHEMBL10960457 | 0.83 | SIRT2 (0.49) | TGM2SIRT2SIRT1SIRT3SIRT5 | |
| Hydrochloric Acid SCHEMBL10946482 | 0.83 | SIRT2 (0.49) | TGM2SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL2268022 | 0.79 | SIRT5 (0.57) | TGM2SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL1088124 | 0.79 | SSTR3 (0.54) | SIRT2SIRT1SIRT3CTSLSIRT5 | |
| SCHEMBL2007479 | 0.78 | PPIA (0.43) | MEN1LMNAKMT2ATGM2SIRT5 | |
| Hydrochloric Acid SCHEMBL10884941 | 0.78 | SIRT5 (0.56) | TGM2SIRT2SIRT1SIRT3SIRT5 | |
| Hydrochloric Acid SCHEMBL10943848 | 0.78 | SIRT5 (0.56) | TGM2SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL1529286 | 0.78 | SIRT2 (0.48) | MEN1LMNAKMT2ASIRT2SIRT1 | |
| Hydrochloric Acid SCHEMBL10946501 | 0.77 | ALDH1A1 (0.41) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5028526-A | Applying to a membrane which allows plasma to pass through and retains the particles | Deutsch, Alice (US) | 1991-07-02 | — | — | US | claimed |
| US-5185246-A | Using membrane with specific pore size to trap particles and pass seminal plasma | DEUTSCH ALICE (US) | 1993-02-09 | — | — | US | disclosed |
| US-5028526-A | Applying to a membrane which allows plasma to pass through and retains the particles | Deutsch, Alice (US) | 1991-07-02 | — | — | US | disclosed |