Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | HCK | P08631 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.41 |
| ▸ | PRKDC | P78527 | 2/20 | 0.41 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 4/20 | 0.37 |
| ▸ | CDK1 | P06493 | 3/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL944808 | 0.82 | PIK3CA (0.49) | PIK3CAMTOR | |
| SCHEMBL945443 | 0.79 | ALDH1A1 (0.40) | PIK3CACNR2YTHDC1PDE8A | |
| SCHEMBL12537196 | 0.74 | YTHDC1 (0.44) | PIK3CDYTHDC1 | |
| SCHEMBL944935 | 0.73 | P2RX7 (0.46) | CNR2CDK1YTHDC1PDE8A | |
| SCHEMBL14296963 | 0.71 | CCNK (0.47) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL1656940 | 0.71 | KDR (0.46) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL14250346 | 0.70 | YTHDC1 (0.54) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL12537322 | 0.69 | CDK8 (0.42) | KDRPIK3CDABL1EGFRHCK | |
| SCHEMBL8083480 | 0.69 | PIK3CA (0.48) | PIK3CAMTORPIK3CGCTSLCTSB | |
| SCHEMBL14325223 | 0.69 | AHR (0.41) | KDRPIK3CDABL1EGFRHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD. (SG) | 2011-01-13 | — | — | US | disclosed |
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD. (SG) | 2011-01-13 | — | — | US | disclosed |
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD. (SG) | 2011-01-13 | — | — | US | disclosed |
| EP-2209785-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO Pte Ltd (SG) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009045174-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD (SG) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009045174-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD (SG) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | PIK3CA, TPMT, MTOR | KDR 3022/4885PIK3CD 5/4885ABL1 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.