Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CRHBP | P24387 | 1/20 | 0.57 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 5/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9448609 | 0.86 | NPC1 (0.56) | MAPTGAALMNACRHBPCRHR2 | |
| SCHEMBL20997864 | 0.79 | ALDH1A1 (0.45) | MAPTGAALMNAALDH1A1HTT | |
| SCHEMBL17774918 | 0.78 | ALDH1A1 (0.55) | MAPTGAALMNACRHBPCRHR2 | |
| SCHEMBL693662 | 0.77 | NPC1 (0.59) | MAPTGAALMNAALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL454706 | 0.76 | NPC1 (0.58) | MAPTGAALMNAALDH1A1HTT | |
| SCHEMBL10793938 | 0.75 | ALDH1A1 (0.52) | MAPTGAALMNACRHBPCRHR2 | |
| SCHEMBL13605317 | 0.74 | ALDH1A1 (0.54) | MAPTGAALMNACRHBPCRHR2 | |
| SCHEMBL11935932 | 0.74 | HDAC8 (0.56) | MEN1KMT2AAURKARPS6KB1 | |
| SCHEMBL8294937 | 0.73 | MEN1 (0.57) | MEN1KMT2A | |
| SCHEMBL5349826 | 0.73 | ALDH1A1 (0.60) | MAPTGAALMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5215738-A | Used for destroying hypoxic tumor cells | SRI INTERNATIONAL (US) | 1993-06-01 | — | — | US | disclosed |
| WO-1986006628-A1 | BENZAMIDE AND NICOTINAMIDE RADIOSENSITIZERS | SRI INTERNATIONAL (US) | 1986-11-20 | — | — | WO | disclosed |