Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.49 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL454706 | 0.98 | NPC1 (0.58) | NPC1POLBALDH1A1KDM4EMAPT | |
| SCHEMBL456092 | 0.81 | GAA (0.58) | NPC1ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL13605317 | 0.80 | ALDH1A1 (0.54) | NPC1POLBALDH1A1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL10992513 | 0.79 | GAA (0.56) | NPC1ALDH1A1KDM4EMAPTGAA | |
| Hydrochloric Acid SCHEMBL28144970 | 0.79 | NPC1 (0.42) | NPC1POLBALDH1A1KDM4EMAPT | |
| SCHEMBL2805209 | 0.78 | ALDH1A1 (0.68) | NPC1POLBALDH1A1KDM4EMAPT | |
| SCHEMBL9448358 | 0.77 | MAPT (0.57) | NPC1POLBALDH1A1KDM4EMAPT | |
| SCHEMBL31710950 | 0.76 | PRMT6 (0.54) | NPC1POLBALDH1A1KDM4EMAPT | |
| SCHEMBL5612632 | 0.76 | ALDH1A1 (0.47) | NPC1POLBALDH1A1KDM4EMAPT | |
| SCHEMBL10793938 | 0.75 | ALDH1A1 (0.52) | NPC1POLBALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280791-B1 | N-HETEROARYLMETHYL-M-PHENYLENEDIAMINE DERIVATIVE-CONTAINING DYES FOR KERATIN FIBERS AND NOVEL N-HETEROARYLMETHYL-M-PHENYLENEDIAMINE DERIVATIVES | WELLA AG (DE) | 2006-05-03 | — | — | EP | claimed |
| US-6997961-B2 | N-heteroarylmethyl-m-phenylenediamine derivatives-containing dyes for keratin fibers and novel n-heteroarylmethyl-m-phenylenediamine derivatives | WELLA AG (DE) | 2006-02-14 | — | — | US | claimed |
| US-20050081310-A1 | N-heteroarylmethyl-m-phenylenediamine derivatives-containing dyes for keratin fibers and novel n-heteroarylmethyl-m-phenylenediamine derivatives | HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2005-04-21 | — | — | US | claimed |
| EP-1280791-A1 | N-HETEROARYLMETHYL-M-PHENYLENEDIAMINE DERIVATIVE-CONTAINING DYES FOR KERATIN FIBERS AND NOVEL N-HETEROARYLMETHYL-M-PHENYLENEDIAMINE DERIVATIVES | Wella Aktiengesellschaft (DE) | 2003-02-05 | — | — | EP | claimed |
| WO-2002072568-A1 | N-HETEROARYLMETHYL-M-PHENYLENEDIAMINE DERIVATIVE-CONTAINING DYES FOR KERATIN FIBERS AND NOVEL N-HETEROARYLMETHYL-M-PHENYLENEDIAMINE DERIVATIVES | WELLA AKTIENGESELLSCHAFT (DE) | 2002-09-19 | — | — | WO | claimed |
| EP-2421613-A2 | KERATIN DYEING COMPOSITIONS COMPRISING A RADICAL SCAVENGER AND A CHELANT AND USE THEREOF | The Procter & Gamble Company (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010123866-A2 | KERATIN DYEING COMPOSITIONS COMPRISING A RADICAL SCAVENGER AND A CHELANT AND USE THEREOF | THE PROCTER & GAMBLE COMPANY (US) | 2010-10-28 | — | — | WO | disclosed |
| EP-1781240-A1 | KERATIN DYEING COMPOUNDS, KERATIN DYEING COMPOSITIONS CONTAINING THEM, AND USE THEREOF | The Procter and Gamble Company (US) | 2007-05-09 | — | — | EP | disclosed |
| EP-1280791-B1 | N-HETEROARYLMETHYL-M-PHENYLENEDIAMINE DERIVATIVE-CONTAINING DYES FOR KERATIN FIBERS AND NOVEL N-HETEROARYLMETHYL-M-PHENYLENEDIAMINE DERIVATIVES | WELLA AG (DE) | 2006-05-03 | — | — | EP | disclosed |
| WO-2006026487-A1 | KERATIN DYEING COMPOUNDS, KERATIN DYEING COMPOSITIONS CONTAINING THEM, AND USE THEREOF | THE PROCTER & GAMBLE COMPANY (US) | 2006-03-09 | — | — | WO | disclosed |
| US-6997961-B2 | N-heteroarylmethyl-m-phenylenediamine derivatives-containing dyes for keratin fibers and novel n-heteroarylmethyl-m-phenylenediamine derivatives | WELLA AG (DE) | 2006-02-14 | — | — | US | disclosed |
| US-20050081310-A1 | N-heteroarylmethyl-m-phenylenediamine derivatives-containing dyes for keratin fibers and novel n-heteroarylmethyl-m-phenylenediamine derivatives | HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2005-04-21 | — | — | US | disclosed |
| EP-1280791-A1 | N-HETEROARYLMETHYL-M-PHENYLENEDIAMINE DERIVATIVE-CONTAINING DYES FOR KERATIN FIBERS AND NOVEL N-HETEROARYLMETHYL-M-PHENYLENEDIAMINE DERIVATIVES | Wella Aktiengesellschaft (DE) | 2003-02-05 | — | — | EP | disclosed |
| WO-2002072568-A1 | N-HETEROARYLMETHYL-M-PHENYLENEDIAMINE DERIVATIVE-CONTAINING DYES FOR KERATIN FIBERS AND NOVEL N-HETEROARYLMETHYL-M-PHENYLENEDIAMINE DERIVATIVES | WELLA AKTIENGESELLSCHAFT (DE) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050081310-A1 | N-heteroarylmethyl-m-phenylenediamine derivatives-containing dyes for keratin fibers and novel n-heteroarylmethyl-m-phenylenediamine derivatives | KRT18, VIM, KPNB1 | NPC1 2541/4885POLB 2402/4885ALDH1A1 1454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.