SCHEMBL9449558

SCHEMBL9449558

Cc1cccc2c1C(CCC(=O)Cl)c1ccccc1-2.Cc1cccc2c1C(CCC(=O)O)c1ccccc1-2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 3/20 0.40
KMT2A Q03164 1/20 0.37
MYC P01106 1/20 0.36
S1PR4 O95977 1/20 0.35
S1PR5 Q9H228 1/20 0.35
PTGER4 P35408 1/20 0.35
PTGER3 P43115 1/20 0.35
PTGER2 P43116 1/20 0.35
ITGB3 P05106 1/20 0.35
ITGAV P06756 1/20 0.35
CYP1A2 P05177 2/20 0.34
TSHR P16473 2/20 0.34
TDO2 P48775 1/20 0.34
HTR7 P34969 1/20 0.33
HTR2B P41595 1/20 0.33
CYP2C19 P33261 1/20 0.33
EDNRB P24530 1/20 0.33
EDNRA P25101 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9449370 0.95 TDO2 (0.37) EGFRKMT2AMYCCYP1A2TSHR
SCHEMBL9449523 0.93 EGFR (0.45) EGFRKMT2AMYCS1PR4S1PR5
SCHEMBL8570074 0.79 KMT2A (0.36) KMT2AHTR7HTR2BALDH1A1HPGD
SCHEMBL8993450 0.79 HTR2A (0.45) EGFRKMT2ACYP1A2TSHRTDO2
SCHEMBL9449455 0.79 MYC (0.43) EGFRMYCCYP1A2TSHRHTR7
SCHEMBL9449741 0.79 EGFR (0.44) EGFRKMT2AS1PR4S1PR5PTGER4
SCHEMBL7606771 0.77 HTR2A (0.44) TDO2HTR7HTR2BALDH1A1
SCHEMBL9449363 0.77 EGFR (0.45) EGFRKMT2AMYCPTGER4PTGER3
SCHEMBL3136529 0.77 EGFR (0.54) EGFRKMT2ACYP1A2TSHR
SCHEMBL28633073 0.76 PTGER4 (0.48) EGFRKMT2APTGER4PTGER3PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0531443-A4 METHODS FOR TREATING INFLAMMATION AND COMPOUNDS AND COMPOSITIONS SUITABLE FOR USE THEREIN 1993-04-21 EP disclosed
EP-0531443-A1 METHODS FOR TREATING INFLAMMATION AND COMPOUNDS AND COMPOSITIONS SUITABLE FOR USE THEREIN NOVA PHARMACEUTICAL CORPORATION (US) 1993-03-17 EP disclosed
WO-1991018596-A1 METHODS FOR TREATING INFLAMMATION AND COMPOUNDS AND COMPOSITIONS SUITABLE FOR USE THEREIN WEITZBERG MOSHE (US) 1991-12-12 WO disclosed