Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3750599 | 0.76 | ATM (0.43) | POLBMAPK1SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL9449692 | 0.75 | GRIN2B (0.50) | GRIN1GRIN2BDRD2DRD3HDAC8 | |
| SCHEMBL4667034 | 0.74 | POLB (0.50) | POLBMAPK1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7472586 | 0.73 | DRD2 (0.48) | GRIN1GRIN2BDRD2DRD3MAPK1 | |
| SCHEMBL8783223 | 0.70 | GRIN2B (0.50) | GRIN1GRIN2BDRD2DRD3HDAC8 | |
| SCHEMBL3756960 | 0.69 | CA1 (0.54) | DRD2DRD3SMN1; SMN2GAANPC1 | |
| SCHEMBL1993959 | 0.69 | LMNA (0.49) | POLBLMNA | |
| SCHEMBL8783295 | 0.68 | GRIN1 (0.54) | GRIN1GRIN2BDRD2DRD3 | |
| SCHEMBL3311831 | 0.68 | MTNR1A (0.64) | GRIN1GRIN2BMAPK1 | |
| SCHEMBL8783707 | 0.67 | GRIN2B (0.67) | GRIN1GRIN2BDRD2DRD3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486969-B2 | Therapeutic compounds | ALLERGAN, INC. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110039864-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2011-02-17 | — | — | US | disclosed |
| WO-2009023752-A1 | ADRENERGIC COMPOUNDS | ALLERGAN, INC. (US) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039864-A1 | THERAPEUTIC COMPOUNDS | ADRB2, ADRB1, ADRB3 | GRIN1 878/4885GRIN2B 1108/4885POLB 3073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.