⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9318305 | 0.74 | — | — | |
| SCHEMBL4845737 | 0.74 | — | — | |
| SCHEMBL5635901 | 0.73 | — | — | |
| SCHEMBL648902 | 0.71 | — | — | |
| SCHEMBL6970369 | 0.71 | — | — | |
| SCHEMBL9832153 | 0.67 | ALDH1A1 (0.50) | — | |
| SCHEMBL28337047 | 0.67 | — | — | |
| SCHEMBL1876546 | 0.67 | — | — | |
| SCHEMBL9026434 | 0.67 | — | — | |
| SCHEMBL6963193 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189891-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-03-27 | — | — | EP | claimed |
| US-6362342-B1 | BIOSYNTHESIS; DRUG LIBRARIES | LION BIOSCIENCE AG (DE) | 2002-03-26 | — | — | US | claimed |
| WO-2001000594-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-01-04 | — | — | WO | claimed |
| CN-1051703-C | Oxaspiro [2,5] octane derivative | FUJISAWA PHARMACEUTICAL CO (JP) | 2000-04-26 | — | — | CN | claimed |
| EP-0359036-B1 | Fumagillol derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-03-26 | — | — | EP | claimed |
| EP-0461427-B1 | Cyclodextrin complex | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-02-19 | — | — | EP | claimed |
| EP-0357061-B1 | Angiogenesis inhibitory agent | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-06-08 | — | — | EP | claimed |
| CN-1024193-C | Process for preparing oxaspiro [2, 5] octane derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-04-13 | — | — | CN | claimed |
| US-5290807-A | Antiinflammatory agents | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 1994-03-01 | — | — | US | claimed |
| CN-1079898-A | Preparation contains the method for the pharmaceutical composition of oxaspiro [2,5] Octane derivatives and salt thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1993-12-29 | — | — | CN | claimed |
| US-5202459-A | Process for producing cyclobutane derivative | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1993-04-13 | — | — | US | claimed |
| US-5196406-A | Antitumor, antiinflammatory | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-03-23 | — | — | US | claimed |
| EP-0461427-A2 | Cyclodextrin complex | Takeda Chemical Industries, Ltd. (JP) | 1991-12-18 | — | — | EP | claimed |
| CN-107158398-A | The MetAP2 inhibitor and its treatment method of application of polymeric conjugation | 辛德弗雷克斯公司 | 2017-09-15 | — | — | CN | disclosed |
| CN-107141410-A | The MetAP2 inhibitor and its treatment method of application of polymeric conjugation | 辛德弗雷克斯公司 | 2017-09-08 | — | — | CN | disclosed |
| CN-103140512-B | Polymer-conjugated MetAP2 inhibitors and methods of treatment using the same | 辛德弗雷克斯公司 | 2017-03-01 | — | — | CN | disclosed |
| US-4395411-A | ANTIBIOTICS; BACTERICIDES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-07-26 | — | — | US | disclosed |
| US-4267176-A | Amino or acylamino-substituted pyrimidinyl cephalosporanic acid derivatives and pharmaceutical compositions thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-05-12 | — | — | US | disclosed |
| US-3992402-A | OR FUNGICIDAL 5-POLYHALOETHYLIMINO- AND 5-POLYHALOVINYLIMINO-2,4-IMIDAZOLIDINEDIONES | CHEVRON RESEARCH COMPANY (US) | 1976-11-16 | — | — | US | disclosed |
| US-3767376-A | HERBICIDES 1-ALIPHATIC-3-ARYL-5-IMINO IMIDAZOLIDINE-2,4-DIONES AND IMIDAZOLIDINE-2-ONE-4-THIONES | CHEVRON RES | 1973-10-23 | — | — | US | disclosed |