Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9451552 | 0.81 | CHEK1 (0.46) | CHEK1 | |
| SCHEMBL15348646 | 0.73 | DYRK1A (0.39) | DYRK1ACHEK1LRRK2PIM1DYRK2 | |
| SCHEMBL9451612 | 0.72 | PDPK1 (0.41) | DYRK1ALRRK2 | |
| SCHEMBL25158209 | 0.72 | CHEK1 (0.41) | DYRK1ACHEK1LRRK2PIM1DYRK2 | |
| SCHEMBL30349391 | 0.72 | CHEK1 (0.41) | DYRK1ACHEK1LRRK2PIM1DYRK2 | |
| SCHEMBL9258260 | 0.63 | ADORA1 (0.40) | CHEK1 | |
| SCHEMBL9451697 | 0.63 | KDM4E (0.30) | — | |
| SCHEMBL31507834 | 0.62 | CHEK1 (0.44) | CHEK1 | |
| SCHEMBL30974980 | 0.62 | NR1I3 (0.52) | DYRK1ACLK2PIM1AXL | |
| SCHEMBL31347233 | 0.61 | KDM4E (0.46) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567223-A1 | Glutamic acid derivatives as antineoplastic agents | ELI LILLY AND COMPANY (US) | 1993-10-27 | — | — | EP | disclosed |
| US-5196424-A | Antitumor | ELI LILLY AND COMPANY (US) | 1993-03-23 | — | — | US | disclosed |