Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 11/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9455039 | 0.94 | OPRL1 (0.49) | DRD4OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL9455234 | 0.91 | OPRL1 (0.46) | DRD4OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL9455311 | 0.86 | OPRL1 (0.49) | DRD4OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL9455304 | 0.82 | OPRM1 (0.43) | DRD4OPRL1OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL9455139 | 0.79 | CCR3 (0.43) | DRD4OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL9455323 | 0.79 | OPRM1 (0.41) | DRD4OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL9455261 | 0.75 | DRD2 (0.41) | DRD4OPRM1DRD2DRD3LMNA | |
| SCHEMBL9455193 | 0.75 | SIGMAR1 (0.56) | DRD4OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL9455021 | 0.74 | CCR3 (0.39) | DRD4OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL9530054 | 0.72 | SIGMAR1 (0.39) | DRD4MAPTSMN1; SMN2DRD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359790-B1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | claimed |
| EP-0359790-B1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5229383-A | Treating psychotic disorders | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-07-20 | — | — | US | disclosed |
| US-5084454-A | Tranquilizers and antinausea drugs | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-01-28 | — | — | US | disclosed |
| EP-0359790-A1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1990-03-28 | — | — | EP | disclosed |
| WO-1989007596-A1 | NEW 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-08-24 | — | — | WO | disclosed |