Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9455312 | 0.86 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| SCHEMBL9455303 | 0.76 | NR3C2 (0.43) | AROPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL9455314 | 0.72 | DRD2 (0.41) | ARSIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL9455237 | 0.71 | SIGMAR1 (0.48) | SIGMAR1DRD2DRD3SMN1; SMN2 | |
| SCHEMBL9455323 | 0.70 | OPRM1 (0.41) | AROPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL9455320 | 0.69 | OPRM1 (0.49) | OPRM1OPRD1OPRK1OPRL1CYP2D6 | |
| SCHEMBL9455021 | 0.67 | CCR3 (0.39) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL9455304 | 0.67 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| SCHEMBL9455261 | 0.66 | DRD2 (0.41) | OPRM1SIGMAR1CYP2D6DRD2DRD4 | |
| SCHEMBL9455311 | 0.65 | OPRL1 (0.49) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359790-B1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5229383-A | Treating psychotic disorders | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-07-20 | — | — | US | disclosed |
| US-5084454-A | Tranquilizers and antinausea drugs | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-01-28 | — | — | US | disclosed |
| EP-0359790-A1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1990-03-28 | — | — | EP | disclosed |
| WO-1989007596-A1 | NEW 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-08-24 | — | — | WO | disclosed |