Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | BAD | Q92934 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 4/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9456422 | 0.80 | HTR1B (0.38) | DRD2DRD3DRD4HTR1ACYP1A2 | |
| SCHEMBL1321391 | 0.76 | BCL2L1 (0.68) | DRD2DRD3DRD4BCL2L1BAD | |
| SCHEMBL2679622 | 0.74 | BCL2L1 (0.42) | DRD2DRD3BCL2L1BADHPGD | |
| SCHEMBL31103410 | 0.74 | BCL2L1 (0.42) | DRD2DRD3BCL2L1BADHPGD | |
| SCHEMBL9390006 | 0.68 | DRD2 (0.54) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL9394757 | 0.64 | DRD2 (0.38) | DRD2DRD3HPGDDRD1DRD5 | |
| SCHEMBL7519114 | 0.63 | MTNR1A (0.46) | DRD2 | |
| SCHEMBL5705483 | 0.63 | DRD2 (0.52) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL6542200 | 0.63 | ALDH1A1 (0.47) | DRD2DRD3DRD4BCL2L1BAD | |
| SCHEMBL11444500 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140350064-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS MOUNTAIN LLC | 2014-11-27 | — | — | US | claimed |
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | claimed |
| US-20140350064-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS MOUNTAIN LLC | 2014-11-27 | — | — | US | disclosed |
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | disclosed |
| EP-0360077-B1 | USE OF SEROTONIN ANTAGONISTS IN THE TREATMENT OF APOPLEXIA CEREBRI | Troponwerke GmbH & Co. KG (DE) | 1993-07-21 | — | — | EP | disclosed |
| US-5200410-A | Serotonin agonist with specific binding strength | TROPONWERKE GMBH & CO. (DE) | 1993-04-06 | — | — | US | disclosed |
| US-5155128-A | Medicaments for the treatment of cerebral apoplexy | TROPONWERKE GMBH & CO. (DE) | 1992-10-13 | — | — | US | disclosed |
| US-5070102-A | SEROTONIN AGONISTS | TROPONWERKE GMBH & CO. (DE) | 1991-12-03 | — | — | US | disclosed |
| US-4988700-A | Antiserotonin agent, aryl or heteroaryl piperazine compounds | TROPONWERKE GMBH & CO. (DE) | 1991-01-29 | — | — | US | disclosed |
| EP-0360077-A2 | Use of serotonin antagonists in the treatment of apoplexia cerebri | Troponwerke GmbH & Co. KG (DE) | 1990-03-28 | — | — | EP | disclosed |