Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25612545 | 0.90 | ALDH1A1 (0.36) | NAAAKMT2AMEN1 | |
| SCHEMBL3707695 | 0.86 | FFAR4 (0.46) | NAAAKMT2AMEN1 | |
| SCHEMBL3700286 | 0.84 | NAAA (0.44) | NAAA | |
| SCHEMBL10419766 | 0.83 | FNTA (0.35) | NAAAKMT2AMEN1 | |
| SCHEMBL10419767 | 0.83 | FNTA (0.35) | NAAAKMT2AMEN1 | |
| SCHEMBL10419765 | 0.83 | FNTA (0.35) | NAAAKMT2AMEN1 | |
| SCHEMBL9457368 | 0.82 | GPR84 (0.41) | KMT2AMAPTMEN1 | |
| SCHEMBL9457193 | 0.82 | GPR84 (0.41) | KMT2AMAPTMEN1 | |
| SCHEMBL10928665 | 0.82 | — | — | |
| SCHEMBL10928661 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246960-A | Used to treat obesity, hyperlipaemia, atherosclerosis and arteriosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1993-09-21 | — | — | US | disclosed |
| US-5175186-A | Inhibits pancreas lepase and useful agent in treatment of obesity, hyperlipemia, atherosclerosis and arteriosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1992-12-29 | — | — | US | disclosed |
| EP-0185359-B1 | OXETANONE | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-04 | — | — | EP | disclosed |
| US-4931463-A | PANCREAS LIPASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1990-06-05 | — | — | US | disclosed |
| EP-0185359-A2 | Oxetanone | F. HOFFMANN-LA ROCHE AG (CH) | 1986-06-25 | — | — | EP | disclosed |