Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 12/20 | 0.51 |
| ▸ | DRD2 | P14416 | 11/20 | 0.51 |
| ▸ | DRD3 | P35462 | 11/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9474371 | 0.87 | HTR3E (0.64) | DRD4DRD2DRD3HTR3EHTR3B | |
| SCHEMBL9458342 | 0.85 | HTR3E (0.62) | DRD4DRD2HTR3EHTR3BHTR3A | |
| SCHEMBL9622510 | 0.82 | DRD4 (0.55) | DRD4DRD2DRD3HTR3A | |
| SCHEMBL9458047 | 0.77 | HTR3E (0.52) | DRD2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9458257 | 0.73 | HTR3E (0.48) | DRD2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9458602 | 0.73 | HTR3E (0.48) | DRD2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9622772 | 0.72 | DRD4 (0.45) | DRD4DRD2DRD3 | |
| SCHEMBL9474052 | 0.72 | HTR3E (0.46) | DRD2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9458438 | 0.71 | HTR3E (0.46) | DRD4DRD2HTR3EHTR3BHTR3A | |
| SCHEMBL11156714 | 0.71 | DRD2 (0.58) | DRD4DRD2DRD3HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5244907-A | Treatment of serotonin imbalance, increase in gastric motility, antiemetics, antiarrhythmia agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-09-14 | — | — | US | disclosed |
| US-5190953-A | 1-azabicyclo(3.2.1.)octan-5-ylmethyl- or 1-azabicyclo(3.3.1) nonan-5-ylmethyl derivatives of carboxamides, thiocarboxamides or esters, thioesters | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-03-02 | — | — | US | disclosed |