Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.72 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.68 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.68 |
| ▸ | SCN1A | P35498 | 1/20 | 0.68 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.68 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10370436 | 0.99 | HTR1A (0.70) | HTR1ASIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL10857463 | 0.86 | HTR1A (0.55) | HTR1ASIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL9458526 | 0.86 | ADRA1D (0.71) | HTR1ASIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL11854599 | 0.85 | ADRA2A (0.84) | HTR1ASIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL567168 | 0.84 | ADRA1D (0.65) | HTR1ASIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL7362066 | 0.84 | HTR1A (0.73) | HTR1ASIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL6983447 | 0.83 | HTR1A (0.52) | HTR1ASIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL8105769 | 0.83 | HTR1A (0.52) | HTR1ASIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL10833179 | 0.83 | HTR1A (0.52) | HTR1ASIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL6982237 | 0.83 | HTR1A (0.52) | HTR1ASIGMAR1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5221745-A | Antidepressanat, anxiolytic and hypotensive agent | AMERICAN HOME PRODUCTS CORP. (US) | 1993-06-22 | — | — | US | disclosed |
| US-5212170-A | Psychotropic piperidinylmethyl benzodioxans | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-05-18 | — | — | US | disclosed |
| US-5182292-A | Psychotropic piperidinylmethyl benzodioxans | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| US-4579845-A | Antihypertensive cyanoguanidines | BOUCHARA S.A. (FR) | 1986-04-01 | — | — | US | disclosed |