Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | KYNU | Q16719 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458623 | 0.98 | CYP3A4 (0.49) | CYP3A4TSHRLMNAHIF1AKDM4E | |
| SCHEMBL9458607 | 0.88 | CYP3A4 (0.44) | CYP3A4TSHRLMNAHIF1AKDM4E | |
| SCHEMBL27573296 | 0.85 | LMNA (0.47) | CYP3A4TSHRLMNAALDH1A1MAPK1 | |
| SCHEMBL7574163 | 0.80 | CYP3A4 (0.55) | CYP3A4TSHRLMNAHIF1AKDM4E | |
| SCHEMBL27979451 | 0.75 | ALDH1A1 (0.50) | LMNAALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL11434065 | 0.72 | CYP3A4 (0.53) | CYP3A4TSHRKDM4EALDH1A1CYP1A2 | |
| SCHEMBL5328095 | 0.72 | CYP3A4 (0.53) | CYP3A4TSHRLMNAHIF1AKDM4E | |
| SCHEMBL5328091 | 0.72 | CYP3A4 (0.53) | CYP3A4TSHRLMNAHIF1AKDM4E | |
| SCHEMBL5291452 | 0.72 | CYP3A4 (0.53) | CYP3A4TSHRLMNAALDH1A1CYP1A2 | |
| SCHEMBL190036 | 0.70 | LMNA (0.48) | LMNAMAPK1TP53CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5234932-A | Bronchodilators, antiallergens, antiinflammatory agents | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1993-08-10 | — | — | US | disclosed |
| EP-0489831-A1 | Substituted quinolines, their preparation and their use as lipoxygenase inhibitors and/or leukotriene antagonists | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1992-06-17 | — | — | EP | disclosed |
| WO-1991003466-A1 | SUBSTITUTED QUINOLINES | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LØVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB (DK) | 1991-03-21 | — | — | WO | disclosed |