Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734174 | 0.86 | TP53 (0.43) | MAPTTSHRALDH1A1TP53L3MBTL1 | |
| SCHEMBL13008024 | 0.79 | IDO1 (0.55) | KMT2AMEN1LMNAAKR1C3AKR1C1 | |
| SCHEMBL10197495 | 0.79 | IDO1 (0.55) | KMT2AMEN1LMNAAKR1C3AKR1C1 | |
| SCHEMBL3235237 | 0.77 | KMT2A (0.47) | KMT2AMEN1LMNAAKR1C3AKR1C1 | |
| SCHEMBL14369928 | 0.72 | MAPT (0.43) | KMT2AMEN1AKR1C3AKR1C1MAPT | |
| SCHEMBL14369927 | 0.72 | MAPT (0.43) | KMT2AMEN1AKR1C3AKR1C1MAPT | |
| SCHEMBL27763781 | 0.71 | ACHE (0.42) | LMNA | |
| SCHEMBL3338887 | 0.71 | MEN1 (0.45) | KMT2AMEN1LMNAALDH1A1SLC18A3 | |
| SCHEMBL17400432 | 0.71 | HTR2C (0.47) | — | |
| SCHEMBL8168719 | 0.71 | MTNR1A (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5221678-A | Cardiovascular disorders, antiinflammatory agents, antiallergens | MERCK FROSST CANADA, INC. (CA) | 1993-06-22 | — | — | US | disclosed |
| EP-0468785-A2 | (Quinolin-2-ylmethoxy)tetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC. (CA) | 1992-01-29 | — | — | EP | disclosed |