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Dimethylformamide

Dimethylformamide

SCHEMBL9459489

CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O.CN(C)C=O

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ CCKAR P32238 8/20 0.89
▸ CCKBR P32239 8/20 0.89
▸ SCN9A Q15858 8/20 0.64
▸ PSEN1 P49768 1/20 0.49
▸ PSEN2 P49810 1/20 0.49
▸ APH1B Q8WW43 1/20 0.49
▸ NCSTN Q92542 1/20 0.49
▸ APH1A Q96BI3 1/20 0.49
▸ PSENEN Q9NZ42 1/20 0.49
▸ NOTCH1 P46531 1/20 0.49
▸ RBPJ Q06330 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8746538 0.94 CCKAR (1.00) CCKARCCKBRSCN9APSEN1PSEN2
SCHEMBL9526556 0.94 CCKAR (1.00) CCKARCCKBRSCN9APSEN1PSEN2
SCHEMBL8746534 0.94 CCKAR (1.00) CCKARCCKBRSCN9APSEN1PSEN2
SCHEMBL9526550 0.94 CCKAR (1.00) CCKARCCKBRSCN9APSEN1PSEN2
SCHEMBL2539002 0.90 CCKBR (0.90) CCKARCCKBRSCN9A
SCHEMBL9423164 0.83 CCKBR (1.00) CCKARCCKBRSCN9A
SCHEMBL9524843 0.83 CCKBR (1.00) CCKARCCKBRSCN9A
SCHEMBL642206 0.81 CCKBR (0.76) CCKARCCKBRSCN9ANOTCH1RBPJ
SCHEMBL5656206 0.81 CCKBR (0.74) CCKARCCKBR
SCHEMBL644153 0.81 CCKBR (0.74) CCKARCCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5264433-A Benzodiazepine derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-11-23 — — US disclosed