Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 8/20 | 1.00 |
| ▸ | CCKBR | P32239 | 8/20 | 1.00 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.70 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.54 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.54 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.54 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.54 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.54 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.54 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.53 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526556 | 1.00 | CCKAR (1.00) | CCKARCCKBRSCN9APSEN1PSEN2 | |
| SCHEMBL8746534 | 1.00 | CCKAR (1.00) | CCKARCCKBRSCN9APSEN1PSEN2 | |
| SCHEMBL8746538 | 1.00 | CCKAR (1.00) | CCKARCCKBRSCN9APSEN1PSEN2 | |
| SCHEMBL2539002 | 0.95 | CCKBR (0.90) | CCKARCCKBRSCN9A | |
| Dimethylformamide SCHEMBL9459489 | 0.94 | CCKAR (0.89) | CCKARCCKBRSCN9APSEN1PSEN2 | |
| SCHEMBL642206 | 0.86 | CCKBR (0.76) | CCKARCCKBRSCN9ANOTCH1RBPJ | |
| SCHEMBL9423164 | 0.86 | CCKBR (1.00) | CCKARCCKBRSCN9A | |
| SCHEMBL9524843 | 0.86 | CCKBR (1.00) | CCKARCCKBRSCN9A | |
| SCHEMBL644153 | 0.86 | CCKBR (0.74) | CCKARCCKBR | |
| SCHEMBL5656206 | 0.86 | CCKBR (0.74) | CCKARCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167919-B1 | BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1993-05-05 | — | — | EP | claimed |
| EP-0167919-A2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | claimed |
| EP-0167919-B1 | BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1993-05-05 | — | — | EP | disclosed |
| US-5004741-A | Cholecystokinin(CCK); Treating Disorders Of The Gastrointestinal Tract, Central Nervous System And Of The Appetite Of Animals | MERCK & CO., INC. (US) | 1991-04-02 | — | — | US | disclosed |
| US-4820834-A | Benzodiazepine analogs | MERCK & CO., INC. (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0284256-A1 | Benzodiazepine analogs | MERCK & CO. INC. (US) | 1988-09-28 | — | — | EP | disclosed |
| EP-0167919-A2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | disclosed |