Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 11/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946007 | 1.00 | S1PR1 (0.50) | S1PR1ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL29352006 | 1.00 | S1PR1 (0.50) | S1PR1ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL945878 | 0.92 | ALDH1A1 (0.47) | S1PR1ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL945876 | 0.92 | ALDH1A1 (0.47) | S1PR1ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL945949 | 0.90 | KMT2A (0.50) | S1PR1ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL945951 | 0.90 | KMT2A (0.50) | S1PR1ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL944317 | 0.89 | L3MBTL1 (0.54) | ALDH1A1MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL944316 | 0.89 | L3MBTL1 (0.54) | ALDH1A1MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL946887 | 0.82 | KMT2A (0.48) | S1PR1ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL946886 | 0.82 | KMT2A (0.48) | S1PR1ALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885266-B1 | PROCESS FOR THE PREPARATION OF (2Z,5Z)-5-(3-CHLORO-4-((R)-2,3-DIHYDROXYPROPOXY)BENZYLIDENE)-2-(PROPYLIMINO)-3-(O-TOLYL)THIAZOLIDIN-4-ONE AND INTERMEDIATE USED IN SAID PROCESS | ACTELION PHARMACEUTICALS LTD (CH) | 2020-03-18 | — | — | EP | claimed |
| US-9340518-B2 | Process for the preparation of (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropdxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-05-17 | — | — | US | claimed |
| US-20150203459-A1 | PROCESS FOR THE PREPARATION OF [(2Z,5Z)-5-(3-CHLORO-4-((R)-2,3-DIHYDROXYPROPOXY)BENZYLIDENE)-2-(PROPYLIMINO)-3-](O-TOLYL)THIAZOLIDIN-4-ONE AND INTERMEDIATE USED IN SAID PROCESS | ACTELION PHARMACEUTICALS, LTD. (CH) | 2015-07-23 | — | — | US | claimed |
| EP-2885266-A1 | PROCESS FOR THE PREPARATION OF!(2Z,5Z)-5-(3-CHLORO-4-((R)-2,3-DIHYDROXYPROPOXY)BENZYLIDENE)-2-(PROPYLIMINO)-3-!(O-TOLYL)THIAZOLIDIN-4-ONE AND INTERMEDIATE USED IN SAID PROCESS | Actelion Pharmaceuticals Ltd. (CH) | 2015-06-24 | — | — | EP | claimed |
| US-8912340-B2 | Process for the preparation of 2-imino-thiazolidin-4-one derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2014-12-16 | — | — | US | claimed |
| WO-2014027330-A1 | PROCESS FOR THE PREPARATION OF|(2Z,5Z)-5-(3-CHLORO-4-((R)-2,3-DIHYDROXYPROPOXY)BENZYLIDENE)-2-(PROPYLIMINO)-3-|(O-TOLYL)THIAZOLIDIN-4-ONE AND INTERMEDIATE USED IN SAID PROCESS | ACTELION PHARMACEUTICALS LTD (CH) | 2014-02-20 | — | — | WO | claimed |
| EP-2094676-B1 | NEW PROCESS FOR THE PREPARATION OF 2-IMINOTHIAZOLIDIN-4-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-04-10 | — | — | EP | claimed |
| US-20120302758-A1 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | VANDA PHARMACEUTICALS INC. | 2012-11-29 | — | — | US | claimed |
| EP-2489662-A1 | New process for the preparation of 2-imino-thiazolidin-4-one derivatives | Actelion Pharmaceuticals Ltd. (CH) | 2012-08-22 | — | — | EP | claimed |
| US-20110201821-A2 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATES | VANDA PHARMACEUTICALS INC. | 2011-08-18 | — | — | US | claimed |
| US-20100317867-A1 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-12-16 | — | — | US | claimed |
| JP-2010510976-A | — | — | 2010-04-08 | — | — | JP | claimed |
| EP-2094676-A2 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2009-09-02 | — | — | EP | claimed |
| WO-2008062376-A2 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-05-29 | — | — | WO | claimed |
| WO-2023152691-A1 | PROCESS FOR THE PREPARATION OF PONESIMOD AND ITS INTERMEDIATES THEREOF | METROCHEM API PVT LTD (IN) | 2023-08-17 | — | — | WO | disclosed |
| WO-2023152691-A1 | PROCESS FOR THE PREPARATION OF PONESIMOD AND ITS INTERMEDIATES THEREOF | METROCHEM API PVT LTD (IN) | 2023-08-17 | — | — | WO | disclosed |
| US-11014940-B1 | Thiazolidinone and oxazolidinone compounds and formulations | CELGENE CORPORATION (US) | 2021-05-25 | — | — | US | disclosed |
| US-20070082933-A1 | Novel thiazolidin-4-one derivatives | ACTELION PHARMACEUTICALS, LTD. | 2007-04-12 | — | — | US | disclosed |
| EP-1689726-A1 | 5-(BENZ- (Z) -YLIDENE) -THIAZOLIDIN-4-ONE DERIVATIVES AS IMMUNOSUPPRESSANT AGENTS | Actelion Pharmaceuticals Ltd. (CH) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005054215-A1 | 5-(BENZ- (Z) -YLIDENE) -THIAZOLIDIN-4-ONE DERIVATIVES AS IMMUNOSUPPRESSANT AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317867-A1 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | IL4, IL15, IL2 | S1PR1 3394/4885ALDH1A1 1222/4885MEN1 690/4885 |
| US-20110201821-A2 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATES | IL4, IL2, IL15 | S1PR1 3355/4885ALDH1A1 1004/4885MEN1 415/4885 |
| US-20070082933-A1 | Novel thiazolidin-4-one derivatives | TLR4, IL4, IRF3 | S1PR1 2472/4885ALDH1A1 671/4885MEN1 3791/4885 |
| US-11014940-B1 | Thiazolidinone and oxazolidinone compounds and formulations | IL17A, OXA1L, ACOX1 | S1PR1 1435/4885ALDH1A1 130/4885MEN1 1639/4885 |
| US-20120302758-A1 | NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES | IL4, IL15, IL2 | S1PR1 3394/4885ALDH1A1 1222/4885MEN1 690/4885 |
| US-20150203459-A1 | PROCESS FOR THE PREPARATION OF [(2Z,5Z)-5-(3-CHLORO-4-((R)-2,3-DIHYDROXYPROPOXY)BENZYLIDENE)-2-(PROPYLIMINO)-3-](O-TOLYL)THIAZOLIDIN-4-ONE AND INTERMEDIATE USED IN SAID PROCESS | IL15, IL15RA, IL5 | S1PR1 2469/4885ALDH1A1 428/4885MEN1 4267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.