Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.53 |
| ▸ | NPC1 | O15118 | 8/20 | 0.53 |
| ▸ | RAB9A | P51151 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 12/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20788996 | 0.74 | ULK1 (0.52) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20789009 | 0.74 | NPC1 (0.55) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL378949 | 0.73 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL23873646 | 0.72 | NPC1 (0.57) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL1920755 | 0.71 | NPC1 (0.60) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL6393394 | 0.70 | MAPT (0.52) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL12613199 | 0.70 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL10089578 | 0.70 | MAPT (0.58) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL761129 | 0.70 | MAPT (0.58) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL29528582 | 0.70 | MAPT (0.58) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227398-A | BENZODIOXOLE DERIVATIVES AND HEPATOPATHY IMPROVERS COMPRISING THE SAME | TSUMURA & CO. (JP) | 1993-07-13 | — | — | US | disclosed |
| EP-0488144-A1 | Benzodioxole derivatives and hepatopathy improvers comprising the same | TSUMURA & CO. (JP) | 1992-06-03 | — | — | EP | disclosed |